Bacterial Adhesion and Entry into Host Cells

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Bacterial Adhesion and Entry into Host Cells

Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV p...

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Septins Regulate Bacterial Entry into Host Cells

BACKGROUND Septins are conserved GTPases that form filaments and are required in many organisms for several processes including cytokinesis. We previously identified SEPT9 associated with phagosomes containing latex beads coated with the Listeria surface protein InlB. METHODOLOGY/PRINCIPAL FINDINGS Here, we investigated septin function during entry of invasive bacteria in non-phagocytic mamma...

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Host and bacterial adhesion.

Bacterial adhesion is an important step in tissue colonization and depends extensively on the surface properties of a bacterial cell. For many microorganisms the prerequisite for host body occupancy is a break in tissue continuity. The next step is ongoing tissue destruction by products of bacterial metabolism: microbial enzymes and toxins. This happens, for example, in the initial phase of per...

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Entry into host cells by Legionella.

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Portals and Pathways: Principles of Bacterial Toxin Entry into Host Cells

D uring infection, pathogenic microbes actively remodel host cells and tissues to create a more suitable niche for withstanding the rigors of the host environment. One of the most effective remodeling strategies is the generation of protein toxins that modulate important functions of both immune and nonimmune cells. The central importance of toxins to the virulence strategies of pathogens is mo...

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ژورنال

عنوان ژورنال: Cell

سال: 2006

ISSN: 0092-8674

DOI: 10.1016/j.cell.2006.02.012